Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant
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چکیده
منابع مشابه
Arabidopsis kinetochore null2 is an upstream component for centromeric histone H3 variant cenH3 deposition at centromeres.
The centromeric histone H3 variant cenH3 is an essential centromeric protein required for assembly, maintenance, and proper function of kinetochores during mitosis and meiosis. We identified a kinetochore null2 (KNL2) homolog in Arabidopsis thaliana and uncovered features of its role in cenH3 loading at centromeres. We show that Arabidopsis KNL2 colocalizes with cenH3 and is associated with cen...
متن کاملCENP-A and the CENP nomenclature: response to Talbert and Henikoff.
References 1 Bradbury, E.M. (1977) Histone nomenclature. Methods Cell Biol. 16 179–181 2 Talbert, P.B. et al. (2012) A unified phylogeny-based nomenclature fo histone variants. Epigenet. Chromatin 5, 7 3 Lawrence, C.J. et al. (2004) A standardized kinesin nomenclature. J Cell Biol. 167, 19–22 4 Earnshaw, W.C. et al. (2013) Esperanto for histones: CENP-A, no CenH3, is the centromeric histone H3 ...
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Chromosomal instability (CIN) is a hallmark of many cancers and a major contributor to tumorigenesis. Centromere and kinetochore associated proteins such as the evolutionarily conserved centromeric histone H3 variant CENP-A, associate with centromeric DNA for centromere function and chromosomal stability. Stringent regulation of cellular CENP-A levels prevents its mislocalization in yeast and f...
متن کاملDynamics of a novel centromeric histone variant CenH3 reveals the evolutionary ancestral timing of centromere biogenesis
The centromeric histone H3 variant (CenH3) serves to target the kinetochore to the centromeres and thus ensures correct chromosome segregation during mitosis and meiosis. The Dictyostelium H3-like variant H3v1 was identified as the CenH3 ortholog. Dictyostelium CenH3 has an extended N-terminal domain with no similarity to any other known proteins and a histone fold domain at its C-terminus. Wit...
متن کاملLoss of centromeric histone H3 (CENH3) from centromeres precedes uniparental chromosome elimination in interspecific barley hybrids.
Uniparental chromosome elimination occurs in several interspecific hybrids of plants. We studied the mechanism underlying selective elimination of the paternal chromosomes during the early development of Hordeum vulgare × Hordeum bulbosum embryos. The following conclusions regarding the role of the centromere-specific histone H3 variant (CENH3) in the process of chromosome elimination were draw...
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ژورنال
عنوان ژورنال: Chromosome Research
سال: 2013
ISSN: 0967-3849,1573-6849
DOI: 10.1007/s10577-013-9347-y